Classification, clinicopathologic features and treatment of gastric neuroendocrine tumors
نویسندگان
چکیده
منابع مشابه
Clinicopathologic Significance of Gastric Adenocarcinoma with Neuroendocrine Features
PURPOSE Composite neuroendocrine-exocrine carcinomas are malignancies that have two distinct components residing within the same tumor: an adenocarcinomatous portion and a neuroendocrine portion. This is rare in gastric cancers; however, poorly differentiated adenocarcinomas can sometimes reveal evidence of neuroendocrine features (NEF) or be 'mixed endocrine and exocrine carcinomas'. This stud...
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Gastric Neuroendocrine Tumors (NET)s are classified on the basis of criteria that are common to all gastrointestinal and pancreatic neuroendocrine neoplasms. Most neuroendocrine neoplasms of the stomach are NETs –well differentiated, nonfunctioning enterochromaffin–like(ECL) cell carcinoids (ECL cell NETs)-arise predominantly in the corpus-fundus region [1]. Three distinct types are recognized :
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Neoplasms may originate from any of the endocrine cells of the gastric wall, most commonly the enterochromaffinlike (ECL) cells of the oxyntic mucosa. In recent years, the increasing number of screening gastroscopies and biopsies, and the widespread application of sophisticated immunohistochemical stains for neuroendocrine markers, have resulted in the frequent detection of ECL tumors. The latt...
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Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are a heterogeneous group of rare tumors whose site-specific tumor incidence and clinical behavior vary widely. Genetic alterations associated with familial inherited syndromes have been well defined; however, the genetic profile of sporadic tumors is less clear as their tumorigenesis does not appear to be controlled by classic oncogenes s...
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ژورنال
عنوان ژورنال: World Journal of Gastroenterology
سال: 2014
ISSN: 1007-9327
DOI: 10.3748/wjg.v20.i1.118